Publications
This page provides references to publications by Novocell staff and other experts in the fields of stem cell engineering, cell encapsulation and islet transplantation.
Stem Cell Engineering
Characterization and Culture of Human Embryonic Stem Cells (360 KB). L.M. Hoffman and M.K. Carpenter, Nature Biotechnology, Vol. 23, No. 6, pp. 669-708, June 2005.
Efficient Differentiation of Human Embryonic Stem Cells to Definitive Endoderm (1.30 MB). K.A. D’Amour, A.D. Agulnick, S. Eliazer, O.G. Kelly, E. Kroon, and E.E. Baetge, Nature Biotechnology, Vol. 23, No. 12, pp. 1534-1541, December 2005. Supplemental Table and Figures for D’Amour, et al., Nature Biotechnology (2.82 MB)
No Stem Cell is an Islet (Yet). D. Stainier, New England Journal of Medicine, Vol. 354, No. 5, pp. 521-523, February 2, 2006.
Production of Pancreatic Hormone-Expressing Endocrine Cells From Human Embryonic Stem Cells (5.28 MB). K.A. D’Amour, et al., Nature Biotechnology, advance online publication, DOI: 10.1038/nbt1259, pp. 1-10, October 19, 2006.
Towards cell therapy for diabetes. Ole D. Madsen & Palle Serup. A protocol based on pancreatic development efficiently converts human embryonic stem cells into insulin-producing cells. Nature Biotechnology, Volume 24, Number 12, December 2006
Activin A Efficiently Specifies Definitive Endoderm from Human Embryonic Stem Cells Only When Phosphatidylinositol 3-Kinase Signaling Is Suppressed. Amanda B. McLean, Kevin A. D’Amour,Karen L. Jones, Malini Krishnamoorthy, Michael J. Kulik, David M. Reynolds, Alan M. Sheppard, Huiqing Liu Ying Xu,Emmanuel E. Baetge, Stephen Dalton. Stem Cells 2007;25:29–38, January 1, 2007
Cell Encapsulation
Encapsulated Human Islet Allografts: Providing Safety and Efficacy. D.W. Scharp, chapter in Cellular Transplants: From Lab to Clinic, published by Elsevier.
Five-Year Follow-Up After Clinical Islet Transplantation. E.A. Ryan, B.W.Paty, P.A. Senior, D. Bigam, E. Alfadhli, N.M. Kneteman, J.R.T. Lakey, and A.M.J. Shapiro, Diabetes, Vol. 54, No. 7, pp. 2060-2069, July 2005. Reprinted with permission from the American Diabetes Association.
International Trial of the Edmonton Protocol for Islet Transplantation. A.M.J. Shapiro, et al., New England Journal of Medicine, Vol. 355, No. 13, pp. 1318-1330, September 28, 2006.